Background & Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Although biannual ultrasound surveillance with or without α-fetoprotein (AFP) testing is recommended for at-risk patients, sensitivity for early stage HCC, for which potentially curative treatments exist, is suboptimal. We conducted studies to establish the multitarget HCC blood test (mt-HBT) algorithm and cut-off values and to validate test performance in patients with chronic liver disease.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2021
Background & Aims: Hepatocellular carcinoma (HCC) can be treated effectively if detected at an early stage. Recommended surveillance strategies for at-risk patients include ultrasound with or without α-fetoprotein (AFP), but their sensitivity is suboptimal. We sought to develop a novel, blood-based biomarker panel with improved sensitivity for early-stage HCC detection.
View Article and Find Full Text PDFBull Environ Contam Toxicol
September 2020
Thiamethoxam 75 SG has recently got registered for use against shoot borer and termites of sugarcane. It is the only neonicotinoid having label claim against both the major pests of sugarcane. The dissipation kinetics and environmental risk assessment of thiamethoxam 75 SG were studied in a typical tropical sugarcane crop ecosystem as detailed reports are lacking.
View Article and Find Full Text PDF