Development of a Uniform Apheresis Case Report Form for Standardized Collection of Apheresis Data.

Apheresis is performed worldwide for an increasing number of indications. The development of common data elements (CDE) for apheresis related areas may facilitate conduct of new research, enhance quality initiatives including benchmarking, and improve patient care. This report describes the systematic development of the Uniform Apheresis Case Report Form (UACRF) as part of the Apheresis in the United States (ApheresUS) program.

Nuclear bodies: concentrating at an aqueous site.

The second FASEB conference on Nuclear Bodies: Hubs of Genome Activity was held June 2-7, 2024, at Niagara Falls, NY. The central theme was how these protein and RNA-protein complexes that are situated in the nucleus outside the genome support and regulate gene expression. Topics included their relevance to disease, especially cancer, their molecular dynamics, and their phase separation transition properties.

Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and lessons learned.

Almost without exception, scientific breakthroughs are not epistemological orphans. Historians of science have developed a body of scholarship on this, and the cases arising in our era continue to confirm the phenomenon. The work by Katalin Karikó and Drew Weissman that proved foundational for the subsequent development of mRNA vaccines for COVID-19 had its antecedent roots yet is also a striking example of both serendipity and their persistence.