Role of the Microbiome and Diet for Response to Cancer Checkpoint Immunotherapy: A Narrative Review of Clinical Trials.

Purpose Of Review: The advent of checkpoint immunotherapy has dramatically changed the outcomes for patients with cancer. However, a considerable number of patients have little or no response to therapy. We review recent findings on the connection between the gut microbiota and the immune system, exploring whether this link could enhance the effectiveness of immunotherapy.

test of the novel antibiotic lefamulin alone and in combination with doxycycline against .

, a sexually transmitted bacterium, is a significant cause of urethritis in men and various reproductive tract infections in women, including cervicitis, pelvic inflammatory disease, endometritis, and potentially infertility. Treatment has become increasingly challenging due to the emergence of resistance to both first-line (azithromycin) and second-line (moxifloxacin) antibiotics. The need for new treatment options is critical.

Neuromuscular transmission deficits in patients with CMT and ClC-1 inhibition in CMT animal models.

Objective: Charcot-Marie Tooth (CMT) is a hereditary neuropathy characterized by muscle weakness and fatigue with no approved therapies. Preclinical studies implicate neuromuscular junction (NMJ) transmission deficits in muscle dysfunction in CMT. This study aimed to evaluate NMJ function in patients with CMT types 1 and 2, and to determine whether enhancing NMJ transmission can improve muscle function in preclinical CMT models.

Persistent Social Inequality in Adolescent Health Indicators 1991-2022: Trend Study From Denmark.

Objectives: To examine trends in socioeconomic inequality in adolescent health over three decades, across fifteen health indicators: overweight, underweight, headache, stomachache, backpain, emotional symptoms, difficulties falling asleep, loneliness, low life satisfaction, low self-rated heath, smoking, drunkenness, physical inactivity, low vegetable intake, and inadequate toothbrushing.

Methods: The Health Behaviour in School-aged Children (HBSC) study in Denmark included nine identical surveys of 11-15-year-olds from 1991 to 2022, n = 35,423. For each health indicator, we measured absolute and relative socioeconomic inequality by prevalence differences and odds ratios between low and high socioeconomic groups.

Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial.

NMD670 is a first-in-class inhibitor of skeletal muscle-specific chloride channel ClC-1, developed to improve muscle weakness and fatigue in neuromuscular diseases. Preclinical studies show that ClC-1 inhibition enhances muscle excitability, improving muscle contractility and strength. We describe the first-in-human, randomized, double-blind, placebo-controlled study, which evaluated the safety, pharmacokinetics, and pharmacodynamics of single and multiple doses of NMD670 in healthy male and female subjects.