Publications by authors named "T S Leong"
Background: Constrained resources under universal health coverage (UHC) necessitate a balance between medication costs and essential health system requirements. Policymakers practice priority-setting, as either implicit or explicit rationing, embedded in evidence-informed decision-making processes to guide funding decisions. Health technology assessment (HTA) is a method that may assist explicit evidence-informed priority setting.
View Article and Find Full Text PDFNeoadjuvant Chemoradiotherapy in Locally Advanced and Locally Recurrent Colon Cancer.
Clin Oncol (R Coll Radiol)
November 2024
Aims: While systemic management of high risk colon cancer is well addressed, advances in local management remain incremental. This study aims to identify a group of colon cancer patients where local management remains a challenge, and where intensifying local treatment with radiotherapy is potentially beneficial to minimise the risk of an R1 resection.
Materials And Methods: The patients with select cT4 locally advanced primary colon (LAPC) (n = 40) and locally recurrent colon (LRC) (n = 48) adenocarcinomas who received neoadjuvant radiotherapy from 2005 to 2020 were studied.
Article Synopsis
- * Researchers used light to activate specially designed nanoparticles that can increase the permeability of the BSCB, allowing normally restricted peptides to enter the spinal cord without harming the surrounding cells or affecting movement.
- * The method effectively delivered the peptide bombesin into the spinal cord, leading to a quick rise in itching behavior in mice, showcasing potential for non-invasive therapies targeting spinal cord conditions.
Article Synopsis
- Academic-government partnerships are crucial for providing timely evidence to inform decision-making during emergencies, like the COVID-19 pandemic in South Africa, utilizing integrated knowledge translation (KT) approaches.
- The study employed Cochrane's KT Framework to analyze activities, such as producing rapid reviews and engaging stakeholders, that facilitated evidence-informed decision-making.
- Key findings emphasize the significance of authentic partnerships, systematic stakeholder engagement, tailored KT strategies, and the need for ongoing evaluation to improve future emergency response efforts.