Assessment of whole-site methane emissions from anaerobic digestion plants: Towards establishing emission factors for various plant configurations.

This study examines methane (CH) emission factors from biogas and wastewater treatment plants, based on primary and secondary data collected from 109 facilities. Primary emission data were measured at 19 facilities representing prevalent plant configurations across Europe. Statistical analysis highlights two categorical variables, namely primary feedstock and plant size, expressed as CH production (≤250 kgh: small and medium-sized plants, >250 kgh: large plants), each of which has a significant impact on whole-site CH emissions.

Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy.

Background: There have been multiple reports of the anti-IL-4Rα agent, dupilumab, being associated with the onset and/or progression of cutaneous T-cell lymphoma (CTCL).

Objective: We sought to evaluate safety signals associated with dupilumab, with a focus on CTCL, and to evaluate the possible underlying mechanism or mechanisms for the potential association.

Methods: First, we used the Food and Drug Administration's pharmacovigilance database, FAERS (FDA Adverse Event Reporting System), to evaluate whether dupilumab was associated with CTCL, including both positive outcome controls (conjunctivitis, eosinophilia, and arthralgia) and exposure controls (other medications with similar indications, including JAK inhibitors and the anti-IL-13 agent, tralokinumab) to evaluate confounding bias.

[Stress fractures of the growth plates in the fingers of adolescent rock climbers].

Background: Primary periphyseal stress injuries (PPSI) of the hand and fingers are a rare condition overall but are most commonly seen in adolescent rock climbers and is the most common sport-specific injury in young climbers. Early diagnosis and treatment are crucial for a good treatment outcome and to avoid chronic sport-related injury.

Objective: The aim of the study is to introduce the injury to a wider audience.

Zika and Chikungunya in Europe 2100 - A GIS based model for risk estimation.

Background: The spread of vector-borne infectious diseases is determined, among other things, by temperature. Thus, climate change will have an influence on their global distribution. In the future, Europe will approach the temperature optimum for the transmission of ZIKV and CHIKV.