Action of Iron Nitrosyl Complexes, NO Donors, on the Activity of Sarcoplasmic Reticulum Ca-ATPase and Cyclic Guanosine Monophosphate Phosphodiesterase.

The effect of iron nitrosyl complexes, NO donors, of a general formula [Fe(L)(NO)] with functional sulfur-containing ligands (L-3-nitro-phenol-2-yl, 4-nitro-phenol-2-yl, or 1-methyl-tetrazol-5-yl) on the activity of sarcoplasmic reticulum Ca-ATPase and cyclic guanosine monophosphate phosphodiesterase (cGMP PDE) was studied. The test complexes uncoupled the hydrolytic and transport functions of Ca- ATPase, thus disturbing the balance of Ca ions in cells, which may affect the formation of thrombi and adhesion of metastatic cells to the endothelium of capillaries. They also inhibited the activity of cGMP PDE, thereby contributing to the accumulation of the second messenger cGMP.

[Biooxidation of a Double-Refractory Gold-Bearing Sulfide Ore Concentrate].

The efficiency of biooxidation for treatment of a double-refractory gold-bearing sulfide ore concentrate from the Bakyrchik deposit (East Kazakhstan) was defined. The experiments were conducted in two different modes, i.e.

[New anticoagulants in clinical practice. Effectiveness and problems].

We analyze the effectiveness of new oral anticoagulants and antivitamins K for the treatment of patients with venous problems, atrial fibrillation, and acute coronary syndrome with reference to advantages of this therapy and methods of prevention of complications of these conditions.

[Physiological Properties of Acidithiobacillus ferrooxidans Strains Isolated from Sulfide Ore Deposits in Kazakhstan].

Acidithiobacillus ferroxidans strains were isolated from acidophilic microbial communities of Kazakhstan sulfide ore deposits. Their biotechnologically important properties (optimal and maximal growth temperatures and resistance to NaCl) were determined. While temperature optima of the strains were the same (30-32 degrees C), temperature ranges were different.