Publications by authors named "T S Kalinina"
Transiently elevated expression of different forms of brain-derived neurotrophic factor in the neonatal medial prefrontal cortex affected anxiety and depressive-like behaviors in adolescence.
PeerJ
December 2024
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) is vital for nerve cell growth and survival, with forms that bind to different receptors affecting brain development, especially during the neonatal period.
- Disruptions in BDNF levels during this critical time can lead to long-term behavioral issues, including increased anxiety and depression in adolescents.
- The study found that elevated levels of mature BDNF contributed to these behaviors, while mutant BDNF led to opposite transcriptional changes, suggesting a significant link between BDNF variations and the development of neurobehavioral disorders.
In this work, we have analyzed the transcriptomic changes in the brainstem of male Wistar rats 2 h after an acute stress exposure. We performed duplex-specific nuclease normalization of cDNA libraries and compared the results back-to-back for the first time. Based on our RNAseq data, we selected reference genes for RT-qPCR that are best suited for acute stress experiments.
View Article and Find Full Text PDFBackground And Purpose: One of the most important mechanisms of tissue regeneration is the high functional activity of cells, including proliferation. Currently, there are practically no effective skin cell activators on the pharmaceutical market. The purpose of this work was to demonstrate the stimulating effect of spiroconjugated 1,2,3-triazolo[5,1-]1,3,4-thiadiazine (STT) on the functional activity of fibroblasts.
View Article and Find Full Text PDFSmoking is an established risk factor for a variety of malignant tumors, the most well-known of which is lung cancer. Various molecular interactions are known to link tobacco smoke exposure to lung cancer, but new data are still emerging on the effects of smoking on lung cancer development, progression, and tumor response to therapy. In this study, we reveal in further detail the previously established association between smoking and hsa-mir-301a activity in lung squamous cell carcinoma, LUSC.
View Article and Find Full Text PDFSmoking is a risk factor for non-small cell lung cancer (NSCLC). The most common subtypes of NSCLC are lung adenocarcinoma (LAC) and squamous cell carcinoma (SCC). The cigarette smoke contains aryl hydrocarbon receptor (AhR) ligands, such as benzo(a)pyrene (BaP).
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