Publications by authors named "T S Jacques"
We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and cfDNA sequencing results were concordant, with a wider spectrum of mutant alleles and higher degree of intra-tumour heterogeneity captured by the latter, if sufficient circulating tumour-derived DNA (ctDNA) was present. Serial tumour sequencing identified putative drivers of relapse, with alterations in epigenetic drivers being a common feature.
View Article and Find Full Text PDFAims: DNA methylation profiling, recently endorsed by the World Health Organisation (WHO) as a pivotal diagnostic tool for brain tumours, most commonly relies on bead arrays. Despite its widespread use, limited data exist on the technical reproducibility and potential cross-institutional differences. The LOGGIC Core BioClinical Data Bank registry conducted a prospective laboratory comparison trial with 12 international laboratories to enhance diagnostic accuracy for paediatric low-grade gliomas, focusing on technical aspects of DNA methylation data generation and profile interpretation under clinical real-time conditions.
View Article and Find Full Text PDFArticle Synopsis
- Brain surgeons need standardized rules for handling brain tumors during surgery to improve diagnosis and treatment.*
- Right now, guidelines mainly exist for one type of brain tumor, but others could also benefit from these rules.*
- Having experts from different fields work together is important for creating these standardized practices to help patients and research better.*
Article Synopsis
- The study assessed the effects of three types of transcranial electrical stimulation (tES) on peripheral vision in glaucoma patients using a double-masked, placebo-controlled approach with 35 participants.
- Results showed that anodal transcranial direct current stimulation (a-tDCS) significantly improved visual detection accuracy and electrophysiological measures (signal-to-noise ratio and latency) compared to sham stimulation, while other tES methods (tACS and tRNS) did not show significant improvements.
- The findings indicate a-tDCS can enhance vision measures in glaucoma patients, but the overall changes observed were minimal, suggesting further research is needed to explore its effectiveness.
Low-grade gliomas are a cause of severe and often life-long disability in children. Pathology plays a key role in their management by establishing the diagnosis, excluding malignant alternatives, predicting outcomes and identifying targetable genetic alterations. Molecular diagnosis has reshaped the terrain of pathology, raising the question of what part traditional histology plays.
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