Publications by authors named "T S Hamrick"

Introduction: The COVID-19 Community Research Partnership is a population-based longitudinal syndromic and sero-surveillance study. The study includes over 17,000 participants from six healthcare systems in North Carolina who submitted over 49,000 serology results. The purpose of this study is to use these serology data to estimate the cumulative proportion of the North Carolina population that has either been infected with SARS-CoV-2 or developed a measurable humoral response to vaccination.

View Article and Find Full Text PDF

Wall teichoic acid (WTA) comprises a class of glycopolymers covalently attached to the peptidoglycan of gram positive bacteria. In Listeria monocytogenes, mutations that prevent addition of certain WTA decorating sugars are attenuating. However, the steps required for decoration and the pathogenic process interrupted are not well described.

View Article and Find Full Text PDF
Article Synopsis
  • Gravid mice infected with Listeria monocytogenes often cannot clear the infection, leading to pregnancy complications or loss of pregnancy.
  • In a study, pregnant mice were inoculated with different doses of Listeria, resulting in lower fetal weights and some embryonic deaths compared to control mice.
  • Histopathological examinations revealed that significant placental damage occurred when high levels of bacteria were present, suggesting that an acute infection may negatively impact embryonic development and growth.
View Article and Find Full Text PDF

A Listeria monocytogenes glcV mutation precludes the binding of certain listerial phages and produces a profound attenuation characterized by the absence of detectable mutants in the livers and spleens of orally inoculated mice. In vitro, we found that the mutant formed plaques on mouse enterocyte monolayers as efficiently as the parent but the plaques formed were smaller. Intracellular growth rate determinations and examination of infected enterocytes by light and fluorescence microscopy established that the mutant was impaired not in intracellular growth rate but in cell-to-cell spreading.

View Article and Find Full Text PDF

Objective: To determine faculty and administrator perceptions about appropriate behavior in social interactions between pharmacy students and faculty members.

Methods: Four private and 2 public colleges and schools of pharmacy conducted focus groups of faculty members and interviews with administrators. Three scenarios describing social interactions between faculty members and students were used.

View Article and Find Full Text PDF