Publications by authors named "T S Gunasekaran"
The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.
View Article and Find Full Text PDFIntroduction/objectives: The primary objective was to compare the 24-h mean heart rate (HR) provided by a smart collar with 24-h ambulatory electrocardiography (Holter) in healthy dogs. The secondary objective was to compare the 2-min HR values between the two methods during periods of activity and rest.
Animals, Materials, And Methods: Twelve healthy dogs were fitted with both Holter monitors and smart collars.
Article Synopsis
- Genetic research on Alzheimer's disease (AD) has largely concentrated on amyloid-β (Aβ), while this study focuses on understanding the genetic basis of tau pathology to uncover new pathways related to AD.
- A genome-wide association study (GWAS) was conducted using data from the A4 and ADNI studies to analyze genetic variants linked to tau pathology, finding two significant loci and pinpointing certain genes associated with tau deposition.
- Mendelian randomization analyses suggest that the LRRFIP1 protein may have a causal relationship with tau pathology, while the polygenic risk scores showed strong associations with amyloid pathology but not with tau pathology.
Background: Few rare variants have been identified in genetic loci from genome-wide association studies (GWAS) of Alzheimer's disease (AD), limiting understanding of mechanisms, risk assessment, and genetic counseling.
Methods: Using genome sequencing data from 197 families in the National Institute on Aging Alzheimer's Disease Family Based Study and 214 Caribbean Hispanic families, we searched for rare coding variants within known GWAS loci from the largest published study.
Results: Eighty-six rare missense or loss-of-function (LoF) variants completely segregated in 17.
Article Synopsis
- Genetic variants in the ABCA7 gene are linked to a higher risk of Alzheimer's disease (AD), but the exact function of ABCA7 in AD development remains uncertain.* -
- Researchers created a zebrafish model lacking the abca7 gene, revealing that ABCA7 is essential for the expression of neuropeptide Y (NPY) and other neurotrophic factors vital for brain health.* -
- Findings suggest that decreased NPY due to impaired ABCA7 function contributes to synaptic issues and a higher risk of AD, with clinical data showing a correlation between NPY levels and disease progression.*