Publications by authors named "T S Field"
Objective: To evaluate the relationship between infarct pattern, inferred stroke mechanism and risk of recurrence in patients with ischaemic stroke. The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.
Design: We conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.
Background: Stroke secondary to intracranial atherosclerotic disease (ICAD) is associated with high recurrence risk despite currently available secondary prevention strategies. In patients with systemic atherosclerosis, a significant reduction of stroke risk with no increase in intracranial or fatal hemorrhage was seen when rivaroxaban 2.5 mg twice daily was added to aspirin.
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- Non-stenotic carotid plaques, identified as having less than 50% stenosis, are considered a potential factor in ischemic strokes, particularly in patients with low-risk neurological events.
- The study analyzed data from 334 patients who experienced minor neurological symptoms and underwent CT angiography and MRI, finding that nearly 46% had these non-stenotic plaques, with a notable prevalence among those showing DWI-positive ischemia.
- The results indicated that non-stenotic plaques are more common on the side of DWI-positive lesions, suggesting a significant association between these plaques and the risk of ischemic events, as patients with non-stenotic plaques had a 40% higher risk for DWI-positive ischemia.
Background: About 25% of patients with acute ischemic stroke have lacunar infarct on follow-up imaging. In this secondary analysis from the AcT (Alteplase Compared With Tenecteplase) trial, we assessed if there is variation in safety or efficacy of intravenous thrombolysis by infarct type in patients with no visible occlusion. We also determined if this effect differed between tenecteplase and alteplase.
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