Enhanced Photothermal Tumor Ablation Using Polypyrrole-Gold Nanocomposites Activated by Polarized Polychromatic Low-Energy Light: An In Vivo Study.

Photothermal therapy (PTT) offers a minimally invasive approach for cancer treatment, using light energy to selectively heat and destroy cancer cells. Success in PTT depends on efficient, stable, and biocompatible photothermal agents. This study investigates polypyrrole@gold nanocomposites (PPy@Au NCs) as photothermal agents combined with polarized polychromatic low-energy light (PPLEL) to target tumors and limit disease progression.

Photobiological modulation of hepatoma cell lines and hepatitis B subviral particles secretion in response to 650 nm low level laser treatment.

Background: Chronic hepatitis B virus (HBV) infection is a serious global health concern, with an increased incidence and risk of developing cirrhosis and hepatocellular carcinoma (HCC). Patients chronically infected with HBV are likely to experience chronic oxidative stress, leading to mitochondrial dysfunction. Photobiomodulation is induced by the absorption of low-level laser therapy (LLLT) with a red or infrared laser by cytochrome C oxidase enzyme, resulting in mitochondrial photoactivation.

Potential impact of gut Lactobacillus acidophilus and Bifidobacterium bifidum on hepatic histopathological changes in non-cirrhotic hepatitis C virus patients with different viral load.

Background: Composition of gut microbiota has recently been suggested as a key factor persuading the pathogenesis of numerous human diseases including hepatic cirrhosis.

Objective: To evaluate the potential impact of Lactobacillus acidophilus and Bifidobacterium bifidum microbiota on the progression of hepatic histopathological changes among patients with non-cirrhotic chronic hepatitis C (HCV) infection with different viral load. Additionally, to assess fecal composition of Lactobacillus acidophilus ATCC-4356 and Bifidobacterium bifidum ATCC-11863 microbiota genotypes MATERIAL AND METHODS: This study was carried out on 40 non-cirrhotic chronically infected HCV patients, and 10 healthy-controls.

Polypyrrole-Gold nanocomposites as a promising photothermal agent: Preparation, characterization and cytotoxicity study.

Photothermal nanomaterials with near-infrared absorption and high energy conversion efficiency have recently attracted significant interest. Polypyrrole-gold nanocomposites (PPy-Au NCs) as photothermal nanoagents are synthesized using ex-situ polymerization method of the modified pyrrole monomers. Microscopic and spectroscopic characterization techniques are used to reveal the surface structure, composition variation and photoelectric properties of PPy-Au NCs, gold nanorods (Au NRs) and polypyyrole nanoparticles (PPy NPs).

A combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA).

Background: Silver nanoparticles (AgNPs) are potential antimicrobials agents, which can be considered as an alternative to antibiotics for the treatment of infections caused by multi-drug resistant bacteria. The antimicrobial effects of double and triple combinations of AgNPs, visible blue light, and the conventional antibiotics amoxicillin, azithromycin, clarithromycin, linezolid, and vancomycin, against ten clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) were investigated.

Methods: The antimicrobial activity of AgNPs, applied in combination with blue light, against selected isolates of MRSA was investigated at 1/2-1/128 of its minimal inhibitory concentration (MIC) in 24-well plates.