Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation.

Rationale: WW domain-containing oxidoreductase ( ) is a gene associated implicated in both neurologic and inflammatory diseases and is susceptible to environmental stressors. We hypothesize partial loss of Wwox function will result in increased sepsis severity and neuroinflammation.

Methods: mice, generated by CRISPR/Cas9, and mice were treated with intraperitoneal PBS vs LPS (10mg/kg) and euthanized 12 hours post-injection.

Estradiol Concentrations and Wellbeing in Trans People Using Estradiol Hormone Therapy.

Purpose: In trans people undergoing feminizing hormone therapy, optimal estradiol concentrations are unclear, and anecdotally, some individuals desire supraphysiologic estradiol concentrations. We aimed to assess associations between estradiol concentration and psychological distress, well-being, and dysphoria. Second, we aimed to explore relationships between estradiol concentration and the risk of medical conditions potentially associated with estradiol therapy.

Insights into the neurobiology of weight loss after bariatric surgery and GLP-1R agonists.

Obesity and its related complications are growing in prevalence worldwide, with increasing impact to individuals and healthcare systems alike. Currently, the leading treatment approaches for effective and sustained weight loss are bariatric surgery and gut peptide therapeutics. At a high level, both treatment strategies work by hijacking gut-brain axis signaling to reduce food intake.

Controlling the Reaction Pathways of Mixed NOH Reactants in Plasma-Electrochemical Ammonia Synthesis.

Electrochemical activation of dinitrogen (N) is notoriously challenging, typically yielding very low ammonia (NH) production rates. In this study, we present a continuous flow plasma-electrochemical reactor system for the direct conversion of nitrogen from air into ammonia. In our system, nitrogen molecules are first converted into a mixture of NO species in the plasma reactor, which are then fed into an electrochemical reactor.