A Network Biology-Guided Investigation of the Long Noncoding RNAs' Role in Glaucoma.

Glaucoma is a group of eye diseases characterized by progressive harm to the optic nerve that often results in loss of vision and blindness. Recent studies suggest that deregulation in the expression of a particular type of RNAs named long noncoding RNAs (lncRNAs) can impact the development of glaucoma and, hence, are promising targets for drug discovery. LncRNAs are transcripts with a length longer than 200 nucleotides that are not translated into proteins.

Charge-transfer mediated J-aggregation in red emitting ultra-small-single-benzenic -fluorophore crystals.

Red emission in crystals has been observed with an ultra-small-single-benzenic -fluorophore () with a molecular weight (MW) of only 197 Da, bettering the literature report of fluorophores with the lowest MW = 252 Da. Supramolecular extensive hydrogen-bonding and J-aggregate type centrosymmetric discrete-dimers or a 1D chain of s led to red emission ( = 610-636 nm) in crystals. Unlike in the solution phase showing one absorption band, in thin films and in crystals the transition from the S state to both the S state and S state becomes feasible.

Sustainable and solvent-free synthesis of molecules of pharmaceutical importance by ball milling.

The solvent-free mechanochemical reactions under ball milling have emerged as a promising alternative to traditional solution-based chemistry. This approach not only eliminates the necessity for large quantities of solvents and minimizes waste production, but it also facilitates a unique reaction environment that enables strategies, reactions, and compound syntheses that are typically unattainable in solution. This solvent-less synthetic strategy under ball-milling has been well employed in synthetic organic chemistry in accessing various potential organic molecules including pharmaceutically important molecules and pharmaceuticals or drug-molecules.

Mirtazapine: A One-Drug Intervention for the Physical and Psychological Symptoms of End-Stage Renal Disease (ESRD).

Patients with end-stage renal disease (ESRD), especially those on dialysis, experience myriad medical and psychological symptoms that impact theirquality of life. These symptoms range from nausea, emesis, and insomnia to pruritus, anxiety, depression, and loss of appetite. These symptoms often require multiple medications (e.

Physiological monitoring of movement and manoeuvrability during a military skiing exercise.

Introduction: Military forces receive training in various high-altitude warfare techniques to safeguard border regions and lives. Skiing is one of such practices where research evidences are limited. Therefore, a study was conducted to continuously monitor the physiological status of soldiers during military skiing practice to quantify the actual demands.