Publications by authors named "T S Belysheva"
Article Synopsis
- Metastatic colorectal cancer has a low 5-year survival rate of under 15%, with common metastasis sites being the lungs and liver, while skin metastases are rare and often indicate a worse prognosis.
- A case study of a 62-year-old woman revealed skin metastases from rectal cancer developed two years after treatment, confirming these through histological examination, although differing mutations were found between the primary tumor and skin lesions.
- Despite treatment with FOLFOX6 chemotherapy and bevacizumab, the therapy failed, highlighting the need for close monitoring of skin for metastases in rectal cancer patients, as literature suggests median survival after detection is only 8.5 months.
Article Synopsis
- Diagnosing skin diseases in children is complex, and Incontinentia pigmenti (IP) is a rare hereditary condition that can lead to serious complications like squamous cell carcinoma (SCC) in young patients.
- A case study involving a 10-year-old girl with IP highlights the importance of an interdisciplinary approach, with input from multiple specialists including dermatologists, geneticists, and oncologists.
- Genetic evaluations confirmed a mutation in the gene responsible for IP in the family, leading to successful treatment over a 2-year period, while also revealing varied symptoms among affected family members.
Background: A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma.
View Article and Find Full Text PDFThe possibility of reducing the operating temperature of H gas sensor based on ZnO-InO down to room temperature under green illumination is shown. It is found that sensitivity of ZnO-InO composite to H nonmonotonically depends on the oxides' content. The optimal ratio between the components is chosen.
View Article and Find Full Text PDFTarget inhibitors are used for melanoma treatment, and their effectiveness depends on the tumor genotype. We developed a diagnostic biochip for the detection of 39 clinically relevant somatic mutations in the , , , , , and genes. We used multiplex locked nucleic acid (LNA) PCR clamp for the preferable amplification of mutated over wild type DNA.
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