Self-assembled sustainable bionanocomposite hydrogels from chitosan for the combination chemotherapy of hydrophobic and hydrophilic drugs.

Self-assembled hydrogels derived from naturally sourced polymers have gained significant interest in drug delivery applications, owing to their potential, exceptional biocompatibility and sustainable properties. This work presents the development and application of self-assembled nanocomposite hydrogels from chitosan and nanosilver as a pH responsive drug delivery system for the controlled release of doxorubicin and paclitaxel in anticancer therapy. Chitosan was functionalized with 4-formyl benzoic acid for incorporating both hydrophobic and hydrophilic anticancer drugs.

A Self-Skin Permeable Doxorubicin Loaded Nanogel Composite as a Transdermal Device for Breast Cancer Therapy.

Modern drug delivery research focuses on developing biodegradable nanopolymer systems. The present study proposed a polymer-based composite nanogel as a transdermal drug delivery system for the pH-responsive targeted and controlled delivery of anticancer drug doxorubicin (DOX). Nanogels have properties of both hydrogels and nanomaterials.

Molecularly imprinted nanoparticles doped graphene oxide based electrochemical platform for highly sensitive and selective detection of L-tyrosine.

A highly sensitive and selective electrochemical sensor was developed using a surface modified glassy carbon electrode (GCE) through molecularly imprinted polymerization on the surface of vinyltrimethoxysilane (VTMS) coated magnetic nanoparticle (FeO) decorated silver nanoparticles incorporated graphene oxide, GO (VTMS-FeO/AgGO) for L- Tyrosine (Tyr) detection. A molecular imprinting technique based on free radical polymerization was applied to synthesize molecularly imprinted Methacrylic acid (MAA) and Acrylamide (AA) grafted VTMS-FeO/AgGO polymer (MAA/AA-g- VTMS-FeO/AgGO) designated as MIP and non-imprinted polymer (NIP). The structure and morphology of the prepared polymers were FTIR, XRD, FE-SEM and VSM.

Magnetic nanoparticle embedded chitosan-based polymeric network for the hydrophobic drug delivery of paclitaxel.

Safe delivery of hydrophobic drugs to the tumor site is a major problem for the scientific community. To improve the in vivo efficacy of hydrophobic drugs by avoiding solubility concerns and providing targeted delivery by nanoparticle, we have developed robust iron oxide nanoparticles coated chitosan with ([2- (methacryloyloxy) ethyl] trimethyl ammonium chloride) (METAC) [CS-IONPs-METAC-PTX] as a drug carrier for the delivery of hydrophobic drug, paclitaxel (PTX). Drug carrier was characterized using various techniques like FT-IR, XRD, FE-SEM, DLS and VSM.

Detection of chlorpyrifos based on molecular imprinting with a conducting polythiophene copolymer loaded on multi-walled carbon nanotubes.

Molecular imprinting technique (MIT) with electrochemical sensing provides an attractive tool for the fabrication of sensors. Incorporation of conducting copolymer and surface imprinting strategies in the sensing device improves the conducting properties and poor template accessibility, slow binding kinetics at the same time. Here, this technique was employed with conducting polymers with multi-walled carbon nanotubes (MWCNT) to build an electrochemical sensor for detecting Chlorpyrifos (CPF) in vegetable sample solutions.