Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles.

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ()? and 2) what are the underlying neurobiological properties of those regions? We meta-analyse vertex-wise -cortical morphometry (volume, surface area, thickness, curvature and sulcal depth) associations using data from 3 cohorts: the UK Biobank (UKB), Generation Scotland (GenScot), and the Lothian Birth Cohort 1936 (LBC1936), with the meta-analytic = 38,379 (age range = 44 to 84 years old). These -morphometry associations vary in magnitude and direction across the cortex (|β| range = -0.12 to 0.

Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.

Background: Air pollution in later life has been associated with dementia; however, limited research has investigated the association between air pollution across the life course, either at specific life periods or cumulatively. The project investigates the association of air pollution with dementia via a life-course epidemiological approach.

Methods: Participants of the Lothian Birth Cohort, born in 1936, provided lifetime residential history in 2014.

Pre and post diagnostic dementia care in four Scottish prisons.

Background And Purpose: The number of older people in prisons is increasing across the globe. Many have poor physical and mental health, higher prevalence of head injury, cognitive impairment and dementia than found in community populations. Meeting the complex needs of this vulnerable group has become an increasing concern for prison and prison healthcare services.

The Relationship Between Anxiety, Depression and Cognitive Functioning in Older Adults: An Exploratory Cross-Sectional Analysis of Wave 1 Lothian Birth Cohort 1936 Data.

Objectives: To explore the strength of the association between cognitive functioning and depression and anxiety in older people without dementia.

Methods: An exploratory, cross-sectional analysis of Wave 1 (2004-2007) data from the Lothian Birth Cohort 1936 dataset. Three subgroups were based on Hospital Anxiety and Depression Scale (HADS) subscales: no probable anxiety or depression (N = 592), probable anxiety no depression (N = 122), probable depression with/without anxiety (depression) (N = 30).