Publications by authors named "T Rowan McLaughlin"
This retrospective cohort study evaluates the impact of an AI-supported continuous glucose monitoring (CGM) mobile app ("January V2") on glycemic control and weight management in 944 users, including healthy individuals and those with prediabetes or type 2 diabetes (T2D). The app, leveraging AI to personalize feedback, tracked users' food intake, activity, and glucose responses over 14 days. Significant improvements in time in range (TIR) were observed, particularly in users with lower baseline TIR.
View Article and Find Full Text PDFThe classification of type 2 diabetes and prediabetes does not consider heterogeneity in the pathophysiology of glucose dysregulation. Here we show that prediabetes is characterized by metabolic heterogeneity, and that metabolic subphenotypes can be predicted by the shape of the glucose curve measured via a continuous glucose monitor (CGM) during standardized oral glucose-tolerance tests (OGTTs) performed in at-home settings. Gold-standard metabolic tests in 32 individuals with early glucose dysregulation revealed dominant or co-dominant subphenotypes (muscle or hepatic insulin-resistance phenotypes in 34% of the individuals, and β-cell-dysfunction or impaired-incretin-action phenotypes in 40% of them).
View Article and Find Full Text PDFShifts in host-associated microbiomes can impact both host and microbes. It is of interest to understand how perturbations, like the introduction of exogenous chemicals, impact microbiomes. In poison frogs (family Dendrobatidae), the skin microbiome is exposed to alkaloids that the frogs sequester for defense.
View Article and Find Full Text PDFArticle Synopsis
- The opioid crisis has evolved into a global issue affecting various socioeconomic and cultural areas, with traditional treatment methods proving insufficient.
- A narrative review was conducted using multiple databases to explore the complex factors contributing to this epidemic, acknowledging the potential for bias in article selection.
- Despite some progress with Opioid Substitution Therapy, U.S. overdose deaths remain alarmingly high and are projected to increase; the authors suggest a need for a new treatment approach that targets brain neurotransmitter systems for better management.
Background: Research on the use of prophylactic inferior vena cave filter (IVCF) placement prior to metabolic and bariatric surgery (MBS) in high risk patients has yielded conflicting results. We evaluated thrombotic events and mortality in patients with a history of venous thromboembolism (VTE) who underwent IVCF placement in anticipation of MBS.
Methods: We queried the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database for all patients undergoing primary sleeve gastrectomy or Roux-en-Y gastric bypass from 2015 to 2019 with a history of VTE.