Age-Adapted Diagnostic Evaluation and Treatment of Patients With Type I Neurofibromatosis in Germany.

Background: Neurofibromatosis type 1 (NF1) is a rare genetic disorder affecting multiple bodily systems that predisposes to the development of tumors. It affects approximately 1 in 3000 newborns in Germany. Its clinical manifestations are diverse and complex, and its diagnostic and therapeutic management call for specialized knowledge and experience.

Roles for TRPV4 in disease: A discussion of possible mechanisms.

The transient receptor potential vanilloid 4 (TRPV4) ion channel is a ubiquitously expressed Ca-permeable ion channel that controls intracellular calcium ([Ca]) homeostasis in various types of cells. The physiological roles for TRPV4 are tissue specific and the mechanisms behind this specificity remain mostly unclarified. It is noteworthy that mutations in the TRPV4 channel have been associated to a broad spectrum of congenital diseases, with most of these mutations mainly resulting in gain-of-function.

Changes in Individual and Dyadic Sexual Behavior Frequencies During Wartime in Israel: How Much, Who, and Why?

Introduction: Understanding the impact of external stressors on human sexuality, especially during war, remains a complex and understudied area. The study's goals were to observe and understand shifts in sexual behavior during the 2023 Israel-Hamas War, with a focus on gender differences. The primary goal is to explore the anticipated decline in sexual activity during wartime, while remaining open to unexpected findings.

Consensus recommendations on management of selumetinib-associated adverse events in pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas.

Background: Selumetinib is the first approved treatment for pediatric patients with neurofibromatosis type 1 (NF1) and symptomatic, inoperable plexiform neurofibromas (PN) in the EU and US, as well as in multiple other countries. Evidence for the management of selumetinib-associated adverse events (AEs) is mostly limited to clinical trials and expanded-access programs. We gathered a panel of European healthcare practitioners with clinical experience prescribing selumetinib and/or managing pediatric patients with NF1-PN to provide recommendations on the prevention and management of AEs.

Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation.

Aims: Sodium/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart failure independent of raised glucose. Various studies have showed that SGLT2 inhibitors relax arteries, but the underlying mechanisms are poorly understood and responses variable across arterial beds. We speculated that SGLT2 inhibitor-mediated arterial relaxation is dependent upon calcitonin gene-related peptide (CGRP) released from sensory nerves independent of glucose transport.