Publications by authors named "T Rosales"
Article Synopsis
- Sepsis and septic shock are critical health issues linked to high mortality rates, with the inflammatory response playing a major role in organ dysfunction, particularly affecting the cardiovascular system through severe hypotension.* -
- Nitric oxide (NO) is a pivotal factor in both inflammation and cardiovascular issues during sepsis, influencing proteins through post-translational modifications, and DTNB is utilized to study these interactions by targeting reactive thiol groups in proteins.* -
- In experiments with sepsis-induced mice, DTNB treatment reduced lung vascular leakage, lowered nitrite/nitrate levels, and diminished inflammatory markers like IL-1ß, suggesting its potential benefits in managing sepsis-induced inflammation.*
Article Synopsis
- * The study developed a method for radiolabeling anthocyanins and nanoencapsulating them using citrus pectin and lysozyme, resulting in structures that are 190 nm in size and have a consistent spherical shape.
- * Findings showed that nanoencapsulated anthocyanins are absorbed more effectively than free anthocyanins in mice, with improved delivery to various organs, which may enhance their biological effects and potential medical applications.
Most kidney cancers are metabolically dysfunctional, but how this dysfunction affects cancer progression in humans is unknown. We infused C-labelled nutrients in over 80 patients with kidney cancer during surgical tumour resection. Labelling from [U-C]glucose varies across subtypes, indicating that the kidney environment alone cannot account for all tumour metabolic reprogramming.
View Article and Find Full Text PDFSARS-CoV-2infection can induce multisystem inflammatory syndrome in children, which resembles superantigen-induced toxic shock syndrome. Recent work has suggested that the SARS-CoV-2 spike (S) protein could act as a superantigen by binding T cell receptors (TCRs) and inducing broad antigen-independent T cell responses. Structure-based computational modeling identified potential TCR-binding sites near the S receptor-binding domain, in addition to a site with homology to known neurotoxins.
View Article and Find Full Text PDFThe inherent cross-reactivity of the T cell receptor (TCR) is balanced by high specificity, which often manifests in confounding ways not easily interpretable from static structures. We show here that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen derived from mutant and its wild-type (WT) counterpart emerges from motions within the HLA binding groove that vary with the identity of the peptide's first primary anchor. The motions form a dynamic gate that in the complex with the WT peptide impedes a large conformational change required for TCR binding.
View Article and Find Full Text PDF