Publications by authors named "T Ronneburg"

Article Synopsis
  • Polygenic traits are influenced by multiple genes, environmental factors, and gene interactions, making their genetic inheritance complex compared to single-gene Mendelian traits.
  • Chickens were chosen as a model to investigate a major Quantitative Trait Loci (QTL) related to body weight using advanced genomic techniques, including genome-wide association studies (GWAS).
  • The research identified key genetic markers and interactions associated with body weight, revealing specific gene variants linked to growth traits, enhancing our understanding of polygenic traits in animals.
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We compared the genomes of multiple domestic chicken breeds with red and white earlobes to identify the differentiated regions between groups of breeds differing in earlobe color. This was done using a selective sweep mapping approach based on whole-genome sequence data. The most significant selective sweep was identified on chromosome 11, where the white earlobe chicken breeds originated from Mediterranean share a common haplotype, and where multiple candidate genes are located.

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Genetic dissection of highly polygenic traits is a challenge, in part due to the power necessary to confidently identify loci with minor effects. Experimental crosses are valuable resources for mapping such traits. Traditionally, genome-wide analyses of experimental crosses have targeted major loci using data from a single generation (often the F) with individuals from later generations being generated for replication and fine-mapping.

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Fungicide resistance has become a challenging problem in management of Septoria tritici blotch (STB), caused by , the most destructive disease of winter wheat throughout western and northern Europe. To ensure the continued effectiveness of those fungicides currently used, it is essential to monitor the development and spread of such resistance in field populations of the pathogen. Since resistance to the key families of fungicides used for STB control (demethyalation inhibitors or azoles, succinate dehydrogenase inhibitors or SDHIs and Quinone outside Inhibitors or QoIs) is conferred through target-site mutations, the potential exists to monitor resistance through the molecular detection of alterations in the target site genes.

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Article Synopsis
  • A metagenome expression library was developed from the gut symbionts of Trinervitermes trinervoides termites and screened, identifying seven recombinant fosmids with feruloyl esterase (FAE) activities.
  • The sequences of the seven FAE genes were between 260 and 274 amino acids long, showing 45-59% identity with other enzymes in the GenBank database, and included a signature motif associated with serine hydrolases.
  • Six out of the seven FAE genes were successfully expressed in E. coli, with the enzymes displaying optimal activity at temperatures of 40-70 °C and pH levels of 6.5 to 8.0, while demonstrating a substrate preference that
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