Publications by authors named "T Rojas-Moreno"

Escherichia coli is a common uropathogen causing community-acquired urinary tract infections (UTIs). Out of 4735 E. coli community-acquired UTIs, 10.

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Objectives: To analyse the in vitro transfer of the qnrA1 gene by a 50 kb (pSZ50) self-transferable plasmid that derives from a 300 kb plasmid (pSZ300) and to determine the complete nucleotide sequence of plasmid pSZ50.

Methods: Extended-spectrum β-lactamase (ESBL) and plasmid-mediated quinolone resistance (PMQR) genes of an Escherichia coli clinical isolate were analysed. Plasmid analysis included conjugation and selection on seven antibiotics examined by antimicrobial susceptibility testing, RFLP comparison, Southern hybridization, incompatibility group identification and shotgun sequencing.

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Article Synopsis
  • The study focused on the effectiveness of tigecycline against ESBL-producing Enterobacteriaceae and MRSA, which are significant hospital-associated infections.
  • More than 94% of the tested bacterial isolates were found to be susceptible to tigecycline.
  • The minimum inhibitory concentration (MIC) values indicated that tigecycline works well, especially at low concentrations (0.25 to 2 mg/L for ESBL bacteria and 0.125 mg/L for MRSA).
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