Publications by authors named "T Rodriguez Vigil"

Article Synopsis
  • Immune checkpoint blockade (ICB) can induce tumor ferroptosis, but many patients don't respond because tumors evade this process within the tumor microenvironment (TME).
  • Researchers found that SLC13A3 acts as a transporter for itaconate in tumor cells, contributing to resistance against ferroptosis, which weakens tumor immunity and reduces ICB effectiveness.
  • Targeting SLC13A3 through various methods, like genetic alteration or using a specific inhibitor, can sensitize tumors to ferroptosis, slow down tumor growth, and enhance the effectiveness of ICB treatments, highlighting SLC13A3 as a potential target for cancer therapy.
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This study sought to understand the barriers to and facilitators of diabetes self-management education and support (DSMES) referrals and participation from multiple perspectives in New York. Two common barriers emerged: lack of awareness of DSMES services and limited access to DSMES services. Strategies that could improve DSMES referrals and participation include provider education, outreach to eligible patients, and tailoring of DSMES services to meet participants' cultural needs and preferences.

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Lithium is a critical mineral in a wide range of current technologies, and demand continues to grow with the transition to a green economy. Current lithium mining and extraction practices are often highly ecologically damaging, in part due to the large amount of water and energy they consume. Biomineralization is a natural process that transforms inorganic precursors to minerals.

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Biomineralization, the use of biological systems to produce inorganic materials, has recently become an attractive approach for the sustainable manufacturing of functional nanomaterials. Relying on proteins or other biomolecules, biomineralization occurs under ambient temperatures and pressures, which presents an easily scalable, economical, and environmentally friendly method for nanoparticle synthesis. Biomineralized nanocrystals are quickly approaching a quality applicable for catalytic and optoelectronic applications, replacing materials synthesized using expensive traditional routes.

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Itaconate was initially identified as an antimicrobial compound produced by myeloid cells. Beyond its antimicrobial role, itaconate may also serve as a crucial metabolic and immune modulator. We therefore examined the roles of aconitate decarboxylase 1 (Acod1) and itaconate in house dust mite (HDM)-sensitized and -challenged mice, a model of T helper 2 (Th2)-driven allergic airways disease.

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