Publications by authors named "T Roch"
Article Synopsis
- Immunogenicity guidance in the biopharmaceutical industry has evolved significantly over the past 20 years due to initial negative reactions with erythropoietin, leading to stringent practices for all biotherapeutic drugs.
- A recent workshop by the European Bioanalysis Forum highlighted the need to reassess current immunogenicity testing methods, drawing from two decades of experience to suggest more relevant approaches.
- The proposed new paradigm encourages a context-based assessment of immunogenicity risk, viewing it as a pharmacodynamic biomarker, which aims to streamline testing strategies and better allocate resources for patient benefit.
Recent technological advances in the production of in vitro transcribed messenger RNA (IVT-mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not naturally observed in endogenous mRNA, have been implemented primarily to address the issue of immunogenicity and improve its biological performance. However, recent findings suggested pronounced differences between expression levels of IVT-mRNAs with different nucleoside modifications in transfected cells.
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- Human herpesvirus 6 (HHV-6) has two types, HHV-6A and HHV-6B, with HHV-6A being more prevalent in kidney transplant patients.
- A study involving 93 patients showed that HHV-6A was found in over half of the participants, while HHV-6B was much less common, and the viral loads for HHV-6A were significantly higher than those of other viruses tested.
- Despite high levels of HHV-6A, no negative impact on kidney function or overall health was observed in patients one year post-transplant.
Background: Mono and combined reactivation of latent viruses occurs frequently under immunosuppressive therapy in kidney transplant patients. Recently, monitoring torque teno virus (TTV) reactivation came more into focus as a potential biomarker for immune status. The surrogate characteristics of TTV reactivation on acute rejection, and the combined reactivation with other latent viruses such as cytomegalovirus (CMV), human BK virus (BKV), Epstein-Barr virus (EBV), and human herpes virus-6A (HHV-6A) on allograft function, are unknown so far.
View Article and Find Full Text PDFIn this work, the potential of magnetron sputtering, as well as cathodic arc evaporation, is investigated with regard to its suitability as a bipolar plate coating of a PEM fuel cell. For this purpose, Cr and Ti thin films were deposited onto a 0.1 mm SS316L by varying the power and bias voltage.
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