Publications by authors named "T Riis"
Exercise increases blood and lymph flow in working muscles, potentially affecting the bioavailability and effect of subcutaneously administered drugs. The aim of this study was to assess the influence of a single exercise session on pharmacokinetics and pharmacodynamics of a single dose of subcutaneously administered unfractionated heparin. In a crossover design, 15 healthy males underwent four experimental days where 15,000 IU of unfractionated heparin was injected subcutaneously into the thigh of the non-dominant leg.
View Article and Find Full Text PDFEmerging neurostimulation methods aim to selectively modulate deep brain structures. Guiding these therapies has presented a substantial challenge, since imaging modalities such as MRI limit the spectrum of beneficiaries. In this study, we assess the guidance accuracy of a neuronavigation method that does not require taking MRI scans.
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- Severe depression is associated with high activity in the subcallosal cingulate (SCC), and while surgical stimulation can help, existing noninvasive methods haven't targeted deep brain areas effectively.
- A study involving 22 participants tested a new technique using low-intensity focused ultrasonic waves to stimulate the SCC while also measuring brain activity and mood changes.
- Results showed that this stimulation reduced SCC activity and led to significant improvements in mood and depression scores compared to a sham treatment, suggesting potential for new therapeutic approaches targeting deep brain circuits.
Article Synopsis
- Understanding the effects of eutrophication on stream macrophytes is essential for effective environmental management, but their response is complicated due to various habitat factors like light and flow.
- The study examined macrophyte communities in 30 lowland streams, specifically looking at water quality, internal nutrient status, and additional land use data to analyze the impact of eutrophication.
- Results indicated that non-native plant species dominate eutrophic streams, with specific growth strategies correlating to different nutrient conditions, highlighting the complex relationships between macrophyte abundance and eutrophication dynamics.
Introduction And Hypothesis: Despite the high prevalence of fecal incontinence, existing treatment options may be inadequate. Drugs that enhance the tone of the anal sphincter complex could potentially be an effective pharmacological approach. This study investigated the effect of the tricyclic antidepressant imipramine on anal sphincter tone in healthy women, employing anal acoustic reflectometry as the evaluating method.
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