Comparative effects of pilocarpine in different vehicles on pupil diameter in albino rabbits and squirrel monkeys.

Several commercial pilocarpine preparations have been compared for their efficacy of drug delivery as evaluated by changes in pupil diameter, and return to base-line pupil size, in rabbits and squirrel monkeys. Adsorbocarpine, Isoptocarpine, Pilocar, all at 2%, and Pilopine HS gel, 4%, were used. In albino rabbits the order of efficacy, as judged by area under the curve, or maximal pupil diameter change, was Pilopine greater than Isoptocarpine = Adsorbocarpine greater than Pilocar = saline (prepared in this laboratory).

Effects of long-term heat disinfection on Soflens (polymacon) contact lenses.

Soflens (polymacon) contact lenses were subjected to long-term heat disinfection in a carefully controlled laboratory study and in a patient clinical study. No adverse effects were observed on the physical or chemical properties of the lenses other than the deposition of some tear components in a portion of the patient-worn lenses. This was not unexpected since no enzyme or surfactant cleaners were used.

Colorimetric determination of poly(N-vinyl-2-pyrrolidone) in contact lens solutions.

A rapid colorimetric method is presented for the quantitative determination of poly(N-vinyl-2-pyrrolidone) in contact lens solutions. The method is simple, requires no sample pretreatment, and uses only a small volume of sample. The procedure is based on the measurement of the net absorbance of a poly(N-vinyl-2-pyrrolidone)- Congo red complex at 545 nm.