Publications by authors named "T Rico"
Recent reports suggested a role for microtubules in double-strand-DNA break repair. We herein investigated the role of the microtubule-associated protein Tau in radio- and chemotherapy. Noticeably, a lowered expression of Tau in breast cancer cell lines resulted in a significant decrease in mouse-xenograft breast tumor volume after doxorubicin or X-ray treatments.
View Article and Find Full Text PDFThe adaptation of Parenteral Nutrition (PN) to actual energy requirements of hospitalised patients is essential, since excessive and insufficient nutritional intake have been associated with poor clinical outcomes. To evaluate the adaptation of prescribed PN to the estimated nutritional requirements using three predictive equations and the influence of excessive/insufficient nutrient intake on patient clinical outcomes (nutritional parameters, metabolic and infectious complications). Prospective, observational study in hospitalised patients nutritionally assessed.
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- Research suggests that the Tau protein plays a role in chromatin organization and functions in various cell types, including breast cancer cells.
- Tau enhances resistance to histone deacetylase inhibitors by blocking their ability to promote gene expression and alter chromatin structure.
- The study reveals Tau as a "chromatin reader" that interacts with histones, preventing key modifications and compacting chromatin, which could lead to new therapeutic strategies for cancer and neurodegenerative diseases.
Food-insecure college students have expressed frustration toward their academic institution for failing to meet students' needs. However, it is unclear whether campus climate perceptions are related to food insecurity status. We examined the association between campus climate surrounding health and food insecurity status among college students.
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- - Kleine-Levin syndrome (KLS) is a rare disorder causing severe episodes of sleepiness, cognitive issues, and changes in behavior, with unclear causes linked to brain activity and difficult births.
- - A global study identified a significant genetic association (rs71947865) related to KLS, particularly prevalent in patients with difficult birth histories and previously connected to bipolar disorder and schizophrenia.
- - Despite variations in findings across different sample sizes, the research highlights potential genetic and environmental factors, specifically involving circadian rhythms, that may contribute to the risk of developing KLS.