Publications by authors named "T Raudsepp"
The global spread of Oriental Horses in the past 1,500 years through the lens of the Y chromosome.
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- Horses have been shaped by human needs through selective breeding, leading to a very uniform male-specific portion of the Y chromosome (MSY) across modern breeds.
- The study analyzed 1,517 males from 189 horse breeds, revealing the significant influence of Oriental stallions, especially Arabian and English Thoroughbred, over the past few centuries.
- Additionally, the research uncovered two major historical waves of horse dissemination, including the "Spanish influence" from the Iberian Peninsula and the spread during the Ottoman Empire's expansion, highlighting the complex ancestry of modern horses.
Cases of stallion subfertility due to acrosome dysfunction have been recognized since the 1990s. While some of these were observed in stallions with reduced sperm motility and morphology, a more severe form has been reported in stallions with normal-to-excellent sperm quality parameters, which is also uniquely observed in individuals of the Thoroughbred registry. These stallions carry a susceptibility genotype (A/A-A A in the gene FKBP6, exon 5) for Impaired Acrosomal Exocytosis (IAE).
View Article and Find Full Text PDFChromosomal abnormalities are a common cause of human miscarriage but rarely reported in any other species. As a result, there are currently inadequate animal models available to study this condition. Horses present one potential model since mares receive intense gynecological care.
View Article and Find Full Text PDFTwo methods for preimplantation genetic testing (PGT) have been described for equine embryos: trophoblast cell biopsy (TCB) or blastocoele fluid aspiration (BFA). While TCB is widely applied for both in vivo- and in vitro-produced embryos, BFA has been mostly utilized for in vivo-produced embryos. Alternative methods for PGT, including analysis of cell-free DNA (CFD) in the medium where in vitro-produced embryos are cultured, have been reported in humans but not for equine embryos.
View Article and Find Full Text PDFThoroughbred stallions that carry a double-homozygous genotype A/A-A/A for SNPs rs397316122 and rs69101140 in exon 5 of the FKBP6 gene (chr13; EquCab3.0) are uniquely subfertile due to impaired acrosomal exocytosis (IAE). In this study, the sperm proteome in frozen/thawed semen from subfertile Thoroughbred stallions was studied and compared to that of frozen/thawed sperm from fertile Thoroughbred stallions.
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