Bioactivity and molecular docking of lactones isolated from Czerep.

Two cytotoxic sesquiterpene lactones, 17-epichlorohyssopifolin A () and chlorjanerin (), and a monoterpene lactone, loliolide () were isolated from . The cytotoxicity of the total extract and terpenoids - were evaluated against three human cancer cells (HepG2, PC-3, and HT-29), along with the human normal primary epidermal keratinocytes (HEKa) cells. With IC values ranging between 0.

Monoterpene Indole Alkaloids from the Aerial Parts of Induce Cytotoxicity and Apoptosis in Human Adenocarcinoma Cells.

Chromatographic investigation of the aerial parts of the (Apocynaceae) resulted in the isolation of two new monoterpene indole alkaloids, 6--antirhine--methyl () and razyamide (), along with six known compounds, eburenine (), -rhazyaminine (), rhazizine (), 20--sitsirikine (), antirhine (), and 16--stemmadenine--oxide (). The chemical structures were established by various spectroscopic experiments. Compounds - exhibited cytotoxic effects against three cancer cells with IC values ranging between 5.

Modification of Sulfonated Polyethersulfone Membrane as a Selective Adsorbent for Co(II) Ions.

In the current study, a variety of sulfonated polyethersulfone (SPES)-based ion-exchange membranes were prepared and utilized as efficient and selective solid adsorbents for the detection of Co(II) ions in aquatic solutions. SPES membranes were treated with a variety of cations at a 2:1 ratio overnight. The produced materials were assessed via XRD, FT-IR, SEM, and TGA analyses.

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera.

By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery. However, in the recent times, natural compounds regained their position as extremely important source drug leads. Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc.

Rapid and sensitive electrochemical sensor of cross-linked polyaniline/oxidized carbon nanomaterials core-shell nanocomposites for determination of 2,4-dichlorophenol.

Nanocomposites (NCs) of crosslinked polyaniline (CPA)-coated oxidized carbon nanomaterials (OXCNMs) were fabricated as a very sensitive and simple electrochemical sensor to be utilized in 2,4-dichlorophenol (2,4-DCPH) detection. CPA/OXCNMs NCs were prepared by chemical copolymerization of polyaniline with triphenylamine and p-phenylenediamine in the presence of OXCNMs. The CPA/GO-OXSWCNTNCs exhibited a higher affinity for the oxidation of chlorophenols compared to the glassy carbon electrode (GCE), CPA/GCE, and other NCs.