Ru(II)-Catalyzed Redox-Neutral C-H Olefination and Tandem Cyclization with Vinyl Sulfones: Leveraging Sulfinate Anion as a Leaving Group for the Synthesis of 3-Methyleneisoindolin-1-ones.

We developed a Ru(II)-catalyzed redox-neutral C-H olefination of -methoxybenzamides with vinyl sulfones. The reaction is operationally simple and conducted at ambient temperature and does not require silver additives or external oxidants, making it suitable for late-stage functionalization. Notably, we leveraged the leaving group ability of sulfinate anion to synthesize 3-methyleneisoindolin-1-ones through a tandem C-H olefination/cyclization/elimination sequence at ambient temperature.

The Effect of Different Concentrations of Melatonin on the Quality of Frozen and Thawed Semen of Jamnapari Goat.

Antioxidants help safeguard sperm cells from damage during the freeze-thaw process. Melatonin and its metabolites have an antioxidative effect. The current study aimed to evaluate the impact of melatonin supplementation in tris-based extenders at various concentrations (0.

Electrochemical oxygen activation driven by enamine-keto push-pull interactions in triazole-based covalent organic polymers.

We have developed two triazole-based covalent organic polymers (COPs) with donor-acceptor motifs. The keto-enriched COP demonstrated exceptional oxygen activation electrochemical stimuli, driven by strong push-pull interactions. studies and DFT calculations confirmed the critical role of enamine carbon positive charges in enhancing performance, setting new benchmarks in COP design.

Homobimetallic Ruthenium(II) Complexes Catalysed Selective Transfer Hydrogenation of Aldehydes in Water.

Herein we report chemoselective transfer hydrogenation (TH) of aldehydes in aqueous medium using a series of homobimetallic Ru(II) catalysts. Two homobimetallic complexes (Ru1 and Ru3) and one monometallic complex (Ru2) have been employed in the catalytic reduction of aldehydes. Bimetallic complex [(p-cymene)(RuCl)L] (Ru3) is obtained from the reaction of Schiff base ligand 2,2'-((1E,1'E)-((3,3',5,5'-tetraisopropyl-[1,1'-biphenyl]-4,4'diyl)bis(azaneylylidene))bis(methaneylylidene))bis(4-bromophenol) (HL) and characterized by various spectroscopic and analytical techniques.

No difference in osteoarthritis, but less graft failures after 5 years, comparing anatomic double-bundle to anatomic single-bundle ACL reconstruction.

Purpose: The purpose of this study was to compare the incidence of knee osteoarthritis (OA) between the anatomic single-bundle (SB) and anatomic double-bundle (DB) anterior cruciate ligament (ACL) reconstruction technique after 5-year follow-up (FU). Secondary objectives were to compare patient-reported outcome measures (PROMs), clinical examination, activity level, functional tests and graft failures between the two groups.

Methods: The study was a secondary analysis after 5-year FU of a randomized controlled trial (RCT) (Clinical Trials NCT01033188).