1,2,4,5-Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure-activity relationship (SAR) studies and future perspectives.

Malaria is a life-threatening disease that affects tropical and subtropical regions worldwide. Various drugs were used to treat malaria, including artemisinin and derivatives, antibiotics (tetracycline, doxycycline), quinolines (chloroquine, amodiaquine), and folate antagonists (sulfadoxine and pyrimethamine). Since the malarial parasites developed drug resistance, there is a need to develop new chemical entities with high efficacy and low toxicity.

Quantifying Transport, Geometrical, and Morphological Parameters in Li-Ion Cathode Phases Using X-ray Microtomography.

The charge/discharge capabilities of Li-ion cathodes are influenced by the meso-scale geometry, transport properties, and morphological parameters of the constituent phases in the cathode: active material, binder, conductive additive, and pore. Electrode processing influences the structure and attendant properties of these constituents. Thus, performance of the battery can be enhanced by correlating various electrode processing techniques with the charge/discharge behavior in the lithium-ion cathodes.

Solitary Presentation but Multiple Etiologies in Foot: A Case Series.

Introduction: The swellings of foot are common but the lesions of metatarsals are rare. The purpose is to highlight these four cases which had almost common presentations but had different etiologies.

Case Report: A series of four cases all of which had similar presentation, but different etiologies.

Degenerative Sacrolisthesis of S1-S2: A Case Report.

Introduction: Degenerative spondylolisthesis (DS) is usually seen at L4-L5 level and less frequently at L5-S1 level. This is a rare case report of spondylolisthesis of S1 over S2 with lumbarization of S1. Lumbarization of S1 is seen in just 1-2% of the population and to have spondylolisthesis in this segment is even rarer.

A computed tomography morphometric study of occipital bone and C2 pedicle anatomy for occipital-cervical fusion.

Background: Occipital-cervical fusion (OCF) has been used to treat instability of the occipito-cervical junction and to provide biomechanical stability after decompressive surgery. The specific areas that require detailed morphologic knowledge to prevent technical failures are the thickness of the occipital bone and diameter of the C2 pedicle, as the occipital midline bone and the C2 pedicle have structurally the strongest bone to provide the biomechanical purchase for cranio-cervical instrumentation. The aim of this study was to perform a quantitative morphometric analysis using computed tomography (CT) to determine the variability of the occipital bone thickness and C2 pedicle thickness to optimize screw placement for OCF in a South East Asian population.