Study on the effect of Western medicine caltrate D combined with traditional Chinese medicine eight section brocade practice therapy on preventing postmenopausal osteoporosis.

Caltrate D is a commonly used drug in the treatment of postmenopausal osteoporosis (PMOP), but the effect of single application is not ideal. Therefore, to investigate the eight section brocade therapy combined with caltrate D effect in preventing and treating PMOP. From January 2021 to June 2022, 110 postmenopausal women with decreased bone mass were selected and randomized into group A (n = 54) and group B (n = 56).

Strong segregation promotes self-destructive cooperation.

Self-destructive cooperators, which sacrifice themselves for others, challenge traditional group selection theory, as costs often exceed individual benefits. We predict self-destructive cooperators can persist in highly segregated environments where populations are primarily divided into homogenous groups originating from one or two founders. In such contexts, the benefits of self-destructive cooperators remain within homogeneous groups of self-destructive cooperators, preserving the sacrifice value and ensuring its maintenance.

Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.

Objective: To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).

Study Design: This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han).

Omega-6 polyunsaturated fatty acids and their metabolites: a potential targeted therapy for pulmonary hypertension.

Pulmonary hypertension (PH) is a progressive and life-threatening cardiopulmonary disease that is not uncommon. The modulation of the pulmonary artery (PA) involves various fatty acids, including omega-6 polyunsaturated fatty acids (ω-6 PUFAs) and ω-6 PUFAs-derived oxylipins. These lipid mediators are produced through cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), and non-enzymatic pathways.

The reduction effect on sensitization of sesame protein Ses i 3 of ultrasound-assisted glycation treatment through modulation of T cell differentiation.

This study aimed to investigate the potential reduction on the sensitization of sesame protein Ses i 3 through ultrasound-assisted glycation. Ses i 3 was extracted and purified using an immunoaffinity column, and the allergenicity changes of Ses i 3 were assessed by a comprehensive strategy, and T cell polarization was also assessed in vivo. Results showed ultrasound-assisted glycation treated Ses i 3 was more easily digestible; and the cell degranulation model showed the histamine, tryptase, and β-hexosaminidase induced by ultrasound-assisted glycation treatment were significantly decreased; besides, the serological results demonstrated that a notable decrease in the binding ability of immunoglobulin E (IgE) and IgG; finally, a BALB/c mice model demonstrated an alleviation of allergic responses induced by ultrasonic-assisted glycation treatment.