Publications by authors named "T R Southwood"
Background: The use of extracorporeal membrane oxygenation (ECMO) during cardiopulmonary resuscitation (ECPR) is increasing. Prehospital ECPR (PH-ECPR) for out-of-hospital cardiac arrest (OHCA) may improve both equity of access and outcomes but its cost effectiveness has yet to be determined.
Methods: Cost analyses of PH-ECPR was performed utilizing current PH-ECPR trial, NSW Ambulance Cardiac Arrest Registry (CAR), geospatial modelling and in-hospital costings data.
Refractory out-of-hospital cardiac arrest (OHCA) has a very poor prognosis, with survival rates at around 10%. Extracorporeal membrane oxygenation (ECMO) for patients in refractory arrest, known as ECPR, aims to provide perfusion to the patient whilst the underlying cause of arrest can be addressed. ECPR use has increased substantially, with varying survival rates to hospital discharge.
View Article and Find Full Text PDFOutcomes after anti-tumour necrosis factor originator to biosimilar switching in children and young people with juvenile idiopathic arthritis in the UK: a national cohort study.
Lancet Rheumatol
July 2024
Article Synopsis
- The study focused on children and young people with juvenile idiopathic arthritis (JIA) who were switched from anti-TNF biological originators to biosimilars for non-medical reasons, assessing their drug survival and disease activity over 6 months.
- It involved 224 patients, with a significant majority transitioning from adalimumab, etanercept, or infliximab, and a matched cohort of 164 patients who continued on the originator was analyzed using a Cox proportional hazard model.
- The findings indicated that switching to biosimilars did not lead to a higher likelihood of stopping treatment compared to those who remained on the originator, suggesting similar persistence of the medication between the two groups.