Risk stratification in neuroblastoma patients through machine learning in the multicenter PRIMAGE cohort.

Introduction: Neuroblastoma, the most prevalent solid cancer in children, presents significant biological and clinical heterogeneity. This inherent heterogeneity underscores the need for more precise prognostic markers at the time of diagnosis to enhance patient stratification, allowing for more personalized treatment strategies. In response, this investigation developed a machine learning model using clinical, molecular, and magnetic resonance (MR) radiomics features at diagnosis to predict patient's overall survival (OS) and improve their risk stratification.

Protocol for a systematic review and meta-analysis on intention to screen for cervical cancer and predictors among women of reproductive age in Ethiopia.

Introduction: The incidence and fatality rates associated with cervical cancer are continuously decreased by cervical cancer screening. However, in underdeveloped nations such as Ethiopia, very few women have undergone cervical cancer screening. There is a scarcity of nationally summarised data in Ethiopia on women's intention to use cervical cancer screening and its determinants.

Assessment of quitting versus using aspirin therapy in patients with stabilized coronary artery disease after stenting who require long-term oral anticoagulation: Rationale for and design of the AQUATIC double-blind randomized trial.

Background: Antithrombotic management in patients with chronic coronary syndrome and previous stent implantation who require long-term oral anticoagulation is highly challenging in daily practice, especially in those at high residual risk of coronary and vascular events. Dual therapy with oral anticoagulation and aspirin may lead to a higher risk of bleeding, whereas stopping aspirin in high-risk patients with coronary artery disease after percutaneous coronary intervention may lead to recurrent ischaemic events.

Aim: To assess the optimal antithrombotic regimen that should be pursued long term (often lifelong) in these patients.

The IGF2BP1 oncogene is a druggable mA-dependent enhancer of YAP1-driven gene expression in ovarian cancer.

The Hippo/YAP1 signaling pathway regulates normal development by controlling contact inhibition of growth. In cancer, YAP1 activation is often dysregulated, leading to excessive tumor growth and metastasis. SRC kinase can cross talk to Hippo signaling by disrupting adherens junctions, repressing the Hippo cascade, or activating YAP1 to promote proliferation.

Exploring for Nutraceuticals: Cultivation Techniques and Neurotoxin Risk Assessment.

This study investigates the potential of the diatom (PT) as a sustainable and nutritionally valuable food source, focusing on its ability to produce bioactive compounds such as eicosapentaenoic acid, fucoxanthin, chrysolaminarin (CRY) and proteins. PT was cultivated in a flat-plate airlift photobioreactor (FPA-PBR) illuminated with LEDs from two sides. The study aimed to monitor and minimize β-methylamino-L-alanine (BMAA) levels to address safety concerns.