Publications by authors named "T R Sadler"

Integrating science education with social justice is vital for preparing students to critically address significant societal issues like climate change and pandemics. This study examines the effectiveness of socioscientific system modeling as a tool within Justice-Centered Science Pedagogy (JCSP) to enhance middle school students' understanding of social justice science issues. It focuses on how system modeling can scaffold students' reasoning about complex social systems, informed by their lived experiences, cultural backgrounds, and social identities.

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Aim: Three rounds of industrial action (IA) were carried out by junior doctors in the United Kingdom between March and June 2023. We investigated the impact of radiology registrars undertaking IA on the efficiency of a large teaching hospital's radiology department.

Materials And Methods: This service evaluation was registered with the local Quality Surveillance Information System and involved analysing data pertaining to the computed tomography, magnetic resonance imaging, ultrasound, and x-ray studies performed before, during, and after periods of IA.

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Article Synopsis
  • Individuals with germline variants in the PTEN gene experience PTEN hamartoma tumor syndrome (PHTS), which is linked to a higher risk of certain cancers and developmental issues, including autism spectrum disorder (ASD).
  • Despite established prevalence statistics, predicting individual outcomes related to cancer versus ASD/DD in PHTS remains challenging due to the complex roles of PTEN.
  • This study analyzed lymphoblastoid cell lines from PHTS patients, revealing that PTEN mutations affect DNA damage repair efficiency and that those with ASD/DD may have better repair rates compared to other patients, suggesting important links between genetic variants, DNA repair, and clinical phenotypes.
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Numerous conditions can mimic ovarian malignancy. Identifying the origin of a pelvic mass or disseminated peritoneal abnormality on imaging is important to ensure that the patient receives optimal management by the appropriate clinical team. Ovarian cancer mimics include infections and other neoplastic processes, for example, actinomycosis, lymphoma, and sarcoma.

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Background: In response to the 2014 Final Settings Rule issued by the Centers for Medicaid and Medicare Services, home-and-community based services (HCBS) provider organizations strengthened person-centered (PC) planning for HCBS to improve participants' choice and control over their services. Despite the call for widespread adoption of PC services, systemic barriers influence service users' and professionals' experiences in receiving and delivering PC services.

Objective: This study describes the perspectives of HCBS professionals and users on systemic barriers that affect PC HCBS delivery.

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