Representative training data sets are critical for accurate machine-learning classification of microscopy images of particles formed by lipase-catalyzed polysorbate hydrolysis.

Polysorbate 20 (PS20) is commonly used as an excipient in therapeutic protein formulations. However, over the course of a therapeutic protein product's shelf life, minute amounts of co-purified host-cell lipases may cause slow hydrolysis of PS20, releasing fatty acids (FAs). These FAs may precipitate to form subvisible particles that can be detected and imaged by various techniques, e.

Optimizing Falling Drop Hemoglobin Method by Comparing Capillary Versus Venous Blood and Determining the Stability of the Copper Sulfate Solution.

Background: Anemia is a global health issue that affects over 1 billion people and contributes to maternal mortality and birth defects. Low-resource, tropical areas face a dual challenge: high prevalence of anemia and inability to access affordable testing methods. The falling drop hemoglobin method has been developed by our lab to quantify hemoglobin concentration and assess anemia by timing the descent of venous blood in a column of copper sulfate solution, without using electricity or batteries.

Formulation of three tailed bacteriophages by spray-drying and atomic layer deposition for thermal stability and controlled release.

Deep infection is the second most common complication of arthroplasty following loosening of the implant. Antibiotic-loaded bone cements (ALBCs) and high concentrations of systemic broad-spectrum antibiotics are commonly used to prevent infections following injury and surgery. However, clinical data fails to show that ALBCs are effective against deep infection, and negative side effects can result following prolonged administration of antibiotics.