Publications by authors named "T R Orchard"
Objective: To evaluate South Asian (SA) and White (WH) inflammatory bowel disease (IBD) phenotypes, and to explore treatment approach variations between these cohorts in the UK using the IBD BioResource database.
Design: Differences between WH and SA IBD patients were analysed using demographic, phenotypic and outcome data. Drug utilisation patterns and surgical outcomes were assessed in propensity score-matched (PSM) cohorts with multivariable logistic regression, Cox regression and Kaplan-Meier analysis.
Introduction: Musculoskeletal (MSK) injuries and disorders are exceptionally prevalent in the clinical setting. Despite this, physician training in MSK medicine has been historically inadequate contributing to a lack of MSK knowledge, confidence, and clinical skills among postgraduate physicians. The goal of this investigation was to examine the long-term impact of a new preclerkship MSK curriculum implemented by a nationally accredited medical program on postgraduate physician's learning and knowledge retention in the area of MSK medicine.
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- Chemotherapy can lead to cognitive and emotional issues in breast cancer survivors, negatively affecting their quality of life.
- This study aimed to see if diets high in omega-3 fatty acids (EPA+DHA) and low in sucrose could help alleviate these effects in a mouse model.
- Results suggested that low sucrose diets improved long-term memory despite chemotherapy, and EPA+DHA intake had a positive effect on insulin resistance, but more research is needed to fully understand the implications.
Article Synopsis
- * Researchers analyzed data from 503 midlife women, focusing on various HDL components and their changes over time to see their impact on cognitive functions like working memory and processing speed.
- * Findings suggest that higher levels of certain HDL metrics are linked to better memory and cognitive performance, indicating that improving these HDL measures could be beneficial for cognitive health, especially in relation to Alzheimer’s disease.
Chemotherapy agents in breast cancer are associated with chemotherapy-related cognitive impairments (CRCI). Mechanisms are not fully clear, but alterations of glucose and lipid metabolism, neuroinflammation and neurodegeneration may contribute to CRCI. The aim of this study was to investigate the combined effects of a high fat (HF) diet combined with doxorubicin-based chemotherapy on glucose and lipid metabolism, neuroinflammation, and neurodegeneration in mice.
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