Publications by authors named "T R McGinn"
Article Synopsis
- Interferons (IFNs) are important for how our bodies respond to viruses, and this study used CRISPR to find human genes affecting SARS-CoV-2 infection with and without IFN.
- The research identified 28 key genes linked to COVID-19, especially those involving the IFN pathway, including PLSCR1, which can limit virus entry without needing IFN.
- PLSCR1’s ability to block SARS-CoV-2 was reduced by the overexpression of TMPRSS2, and some virus variants have evolved to bypass PLSCR1’s defense, suggesting ongoing challenges in controlling the virus.
Background: Inpatient and extended postdischarge thromboprophylaxis of COVID-19 patients remains suboptimal despite antithrombotic guidelines.
Objectives: To determine whether a novel electronic health record-agnostic clinical decision support (CDS) tool incorporating the International Medical Prevention Registry on Venous Thromboembolism plus D-dimer (IMPROVE-DD) venous thromboembolism (VTE) scores increases appropriate inpatient and extended postdischarge thromboprophylaxis and improves outcomes in COVID-19 inpatients.
Methods: This post hoc analysis of the IMPROVE-DD cluster randomized trial evaluated thromboprophylaxis CDS among COVID-19 inpatients at 4 New York hospitals between December 21, 2020, and January 21, 2022.
Objective: Our objective was to determine the feasibility and preliminary efficacy of a behavioral nudge on adoption of a clinical decision support (CDS) tool.
Materials And Methods: We conducted a pilot cluster nonrandomized controlled trial in 2 Emergency Departments (EDs) at a large academic healthcare system in the New York metropolitan area. We tested 2 versions of a CDS tool for pulmonary embolism (PE) risk assessment developed on a web-based electronic health record-agnostic platform.
Background: Thromboprophylaxis for medically ill patients during hospitalization and postdischarge remains underutilized. Clinical decision support (CDS) may address this need if embedded within workflow, interchangeable among electronic health records (EHRs), and anchored on a validated model.
Objectives: The purpose of this study was to assess the clinical impact of a universal EHR-integrated CDS tool based on the International Medical Prevention Registry on Venous Thromboembolism plus D-Dimer venous thromboembolism model.
Background: Few patient engagement tools incorporate the complex patient experiences, contexts, and workflows that limit depression treatment implementation.
Objective: Describe a user-centered design (UCD) process for operationalizing a preference-driven patient activation tool.
Design: Informed by UCD and behavior change/implementation science principles, we designed a preference-driven patient activation prototype for engaging patients in depression treatment.