Publications by authors named "T R Hadley"

Whānau Pakari is a family-centred healthy lifestyle programme for children/adolescents with overweight/obesity in New Zealand. This secondary analysis from our randomised trial within the clinical service assessed 5-year BMI changes in accompanying caregivers (n = 23), mostly mothers. Overall, baseline and 5-year caregivers' BMI were similar (32.

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Article Synopsis
  • Severe hypertriglyceridemia often results from genetic factors, including rare pathogenic variants and common genetic variations assessed via polygenic risk scores (PRS).
  • In a study of 363 patients, those with both pathogenic variants and high PRS had a significantly increased risk of very severe hypertriglyceridemia and acute pancreatitis, compared to those without these genetic risk factors.
  • The findings suggest that genetic testing could be valuable in identifying patients at high risk for pancreatitis, potentially guiding targeted treatment strategies for hypertriglyceridemia.
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Background: Routine genome-wide screening for cardiovascular disease risk may inform clinical decision-making. However, little is known about whether clinicians and patients would find such testing useful or acceptable within the context of a genomics-enabled learning health system.

Methods: We conducted surveys with patients and their clinicians who were participating in the HeartCare Study, a precision cardiology care project that returned results from a next-generation sequencing panel of 158 genes associated with cardiovascular disease risk.

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Objectives: We examined whether caregivers of children/adolescents enroled in a randomised controlled trial (RCT) of a family-centred intervention indirectly achieved reductions in body mass index (BMI), and if these were associated with changes in their children's BMI.

Methods: RCT participants were New Zealand children/adolescents aged 4.8-16.

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This study examined whether behavioral health service use post-jail release was associated with reduced risk of jail reincarceration. The study sample included 20,615 individuals who had behavioral health diagnoses and were released from the Philadelphia County jail. Using administrative records of the county jail and state-, county-, and Medicaid-funded behavioral health service use from 2010 to 2018, we conducted Cox proportional hazard analyses to estimate the association between behavioral health service use post-jail release and the risk of return to jail within 3 years.

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