Publications by authors named "T R Eijgenraam"
Bile acids (BAs) play important roles in the context of lipid homeostasis and inflammation. Based on extensive preclinical mouse studies, BA signaling pathways have been implicated as therapeutic targets for cardiovascular diseases. However, differences in BA metabolism between mice and humans hamper translation of preclinical outcomes.
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- - Elevated levels of plasma bile acids (BAs) in Cyp2c70 mice lead to changes in heart gene expression, indicating stress and inflammation related to cardiac health in early life.
- - RNA sequencing revealed 1355 differentially expressed genes in the hearts of mice with high versus low plasma BAs, with many linked to inflammatory processes and cardiovascular disease.
- - Treatment with ursodeoxycholic acid (UDCA) during pregnancy normalized many of the affected cardiac genes, suggesting potential therapeutic benefits for managing cardiac issues related to elevated BAs.
Background: The p.Arg14del variant of the (phospholamban) gene causes cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear PLN aggregation have both been suggested as pathological drivers of this disease.
View Article and Find Full Text PDFBackground: Relative fat mass (RFM) is a novel sex-specific anthropometric equation (based on height and waist measurements) to estimate whole-body fat percentage.
Objective: To examine associations of RFM with incident type-2 diabetes (T2D), and to benchmark its performance against body-mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR).
Methods: This prospective longitudinal study included data from three Dutch community-based cohorts free of baseline diabetes.
Background: Heart failure (HF) is the leading cause of morbidity and mortality worldwide, and there is an urgent need for more global studies and data mining approaches to uncover its underlying mechanisms. Multiple omics techniques provide a more holistic molecular perspective to study pathophysiological events involved in the development of HF.
Methods: In this study, we used a label-free whole myocardium multi-omics characterization from three commonly used mouse HF models: transverse aortic constriction (TAC), myocardial infarction (MI), and homozygous Phospholamban-R14del (PLN-R14).