Publications by authors named "T R Chauncey"
Introduction: Acute myeloid leukemia (AML) remains one of the deadliest hematopoietic malignancies. A better understanding of the molecular biology governing AML may lead to improved risk stratification and facilitate the development of novel therapies. Proteins are responsible for much of the biology of cells.
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- * Traditional exercise regimens are recommended but poorly maintained among patients; thus, alternative strategies like neuromuscular electrical stimulation are being explored to better support patients during recovery.
- * A randomized controlled trial is investigating the effects of neuromuscular electrical stimulation on physical function and quality of life for patients post-transplant to determine its effectiveness and acceptance as a rehabilitation method.
Background: Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myeloid leukemia. We hypothesized that examining the homogenous leukemic blasts will yield different biological information and may improve prognostic performance of expression biomarkers.
Methods: To assess the impact of cellular heterogeneity on expression biomarkers in acute myeloid leukemia, we systematically examined paired mononuclear cells and viable CD34-expressing leukemic blasts from SWOG diagnostic specimens.
Background: Autologous hematopoietic stem cell transplantation (AHSCT) is associated with sexual dysfunction and hypogonadism. Androgens are associated with sexual function in healthy men, but the role of estrogens is less well-known, and the association of these sex steroids with sexual function during AHSCT has not been characterized.
Objectives: The purpose of this study was to determine the predictive value of sex hormones before and acutely after AHSCT on sexual function recovery.