Publications by authors named "T R Caulfield"
Article Synopsis
- There is growing concern about cancer misinformation on Amazon, particularly regarding books that claim to offer false cancer cures.
- A study examined the top 1000 books listed under "cancer cure" on Amazon, revealing that almost 50% contained misleading information about cancer treatment.
- The misleading books reveal themes like promoting unsupported treatment claims, oversimplifying cancer, and discrediting established medical treatments, highlighting a need for consumer awareness in health-related purchases.
Article Synopsis
- Mutations in the PRKN gene are a leading cause of early-onset Parkinson disease, with the p.R275W variant being the most common among patients.
- Research using patient fibroblasts, isogenic neurons, and human brain samples reveals that the p.R275W mutation significantly reduces PRKN protein levels, impairing mitophagy and mitochondrial degradation.
- Structural simulations indicate that this mutation destabilizes the PRKN protein, leading to a loss-of-function under normal biological conditions.
Aggregated α-synuclein (α-SYN) proteins, encoded by the gene, are hallmarks of Lewy body disease (LBD), affecting multiple brain regions. However, the specific mechanisms underlying α-SYN pathology in cortical neurons, crucial for LBD-associated dementia, remain unclear. Here, we recapitulated α-SYN pathologies in human induced pluripotent stem cells (iPSCs)-derived cortical organoids generated from patients with LBD with gene triplication.
View Article and Find Full Text PDFBackground: Politicization and misinformation or disinformation of unproven COVID-19 therapies have resulted in communication challenges in presenting science to the public, especially in times of heightened public trepidation and uncertainty.
Objective: This study aims to examine how scientific evidence and uncertainty were portrayed in US news on 3 unproven COVID-19 therapeutics, prior to the development of proven therapeutics and vaccines.
Methods: We conducted a media analysis of unproven COVID-19 therapeutics in early 2020.
Background: Complementary and alternative (CAM) cancer treatment is often expensive and not covered by insurance. As a result, many people turn to crowdfunding to access this treatment.
Objective: The aim of this study is to identify the rationales of patients with cancer seeking CAM treatment abroad by looking specifically at crowdfunding campaigns to support CAM cancer treatment in Tijuana, Mexico.