Whispering-gallery mode sensor based on coupling of tapered two-mode fiber and glass capillary.

A novel whispering-gallery mode (WGM) sensor is fabricated by coupling a tapered two-mode fiber and a glass capillary. By utilizing the relatively large orifice of glass capillaries, polydimethylsiloxane (PDMS) and magnetic fluid are directly injected into two WGM structured glass capillaries, respectively, allowing these materials to substantially interact with the light field of the WGM, thereby achieving temperature, pressure, and magnetic field measurements. λ1 and λ2 are the two resonant peak wavelengths of the WGM after injecting PDMS into a glass capillary.

Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway.

Introduction: Bone aging is linked to changes in the lineage differentiation of bone marrow stem cells (BMSCs), which show a heightened tendency to differentiate into adipocytes instead of osteoblasts. The therapeutic potential of irisin in addressing age-related diseases has garnered significant attention. More significantly, irisin has the capacity to enhance bone mass recovery and sustain overall bone health.

Generalizable, sequence-invariant deep learning image reconstruction for subspace-constrained quantitative MRI.

Purpose: To develop a deep subspace learning network that can function across different pulse sequences.

Methods: A contrast-invariant component-by-component (CBC) network structure was developed and compared against previously reported spatiotemporal multicomponent (MC) structure for reconstructing MR Multitasking images. A total of 130, 167, and 16 subjects were imaged using T, T-T, and T-T- -fat fraction (FF) mapping sequences, respectively.

Genetic features and pharmacological rescue of novel Kv7.2 variants in patients with epilepsy.

Background: Increasing evidence indicates a robust correlation between epilepsy and variants of the Kv7.2 () channel, which is critically involved in directing M-currents and regulating neuronal excitability within the nervous system. With the advancement of next-generation sequencing, the identification of variants has surged.

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study.

Objective: This study was to employ 18F-flurodeoxyglucose (FDG-PET) to evaluate the resting-state brain glucose metabolism in a sample of 46 patients diagnosed with disorders of consciousness (DoC). The aim was to identify objective quantitative metabolic indicators and predictors that could potentially indicate the level of awareness in these patients.

Methods: A cohort of 46 patients underwent Coma Recovery Scale-Revised (CRS-R) assessments in order to distinguish between the minimally conscious state (MCS) and the unresponsive wakefulness syndrome (UWS).