Publications by authors named "T R Brum"
This study explores the impact of a simulated radiological dispersal device (RDD) event in an urban area on young adults around 20 years old. The RDD releases radioactive Cs-137 (7.0E+3 Ci), a common industrial sterilization source.
View Article and Find Full Text PDFBackground: After the advent of combination antiretroviral therapy, infection with the human immunodeficiency virus (HIV) ceased to be a devastating disease, but sensory neuropathy resulting from the permanence of the virus and the side effects of treatment have worsened the morbidities of these patients.
Objective: To investigate the quality of life of 64 HIV-positive patients: 24 with painful neuropathy (case group) and 40 without painful neuropathy (control group). The impact of other factors on quality of life was also assessed.
Article Synopsis
- The text discusses the challenges in assessing health risks after a radiological event due to uncertainty in explosion details and radioactive plume behavior.
- The study simulated the release of radioactive Cs-137 and used the HotSpot health physics code to calculate the Total Effective Dose Equivalent (TEDE) in relation to cancer risk.
- Findings indicate a correlation between atmospheric stability and relative cancer risk, which could enhance early emergency response planning by identifying potentially affected populations.
Ethnopharmacological Relevance: Casearia decandra (guaçatonga) is popularly used as an anti-inflammatory. We investigated the antioxidant and anti-inflammatory effect of C.decandra leaves (CdE) ethanolic extract and of the rutin standard (present in the CdE).
View Article and Find Full Text PDFChanges in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil-ANRS 12274.
Front Immunol
September 2020
Article Synopsis
- Tuberculosis (TB) is a major health issue for individuals with HIV, being the leading cause of death, but combined antiretroviral therapy (cART) can help improve survival, despite issues like immune reconstitution inflammatory syndrome (IRIS).
- The study evaluated various types of innate lymphocytes in TB/HIV patients, including natural killer (NK) and γδ T cells, using flow cytometry, comparing them to patients with only TB or HIV and healthy controls.
- Findings showed significant changes in NK cell activation markers in TB/HIV patients, particularly those with IRIS, and highlighted an increased presence of certain γδ T cell subsets, indicating that HIV affects immune cell populations and responses during TB treatment.