Publications by authors named "T R BRADLEY"
Follicular lymphoma (FL) is a disease often characterized by chronic and successive relapses after first-line chemoimmunotherapy. Although chemoimmunotherapy and combination therapy, such as lenalidomide with rituximab, are well established in the treatment sequence of FL, there is a need to streamline treatment options and determine placement of novel agents, such as chimeric antigen receptor T-cell therapy, an enhancer of zeste homolog 2 inhibitor, or a phosphoinositide 3 kinase inhibitor, into the treatment landscape. As such, the purpose of this review is to compare the safety profiles of approved agents in subsequent lines of therapy for relapsed or refractory FL and to assess how the management of adverse events may impact treatment choice.
View Article and Find Full Text PDFObesity factors into hypertrophic cardiomyopathy (HCM)-related risk as a disease modifying environmental factor. Behaviours such as diet and sleep are seldom reported upon in children with HCM. It was our aim to report on these factors in this population.
View Article and Find Full Text PDFSleep disordered breathing (SDB) is considered a risk factor for cardiovascular disease (CVD). Obstructive sleep apnoea (OSA) can be treated with continuous positive airway pressure (CPAP), and central sleep apnoea (CSA), in patients with heart failure with reduced ejection fraction (HFrEF), by peak flow-triggered adaptive servo-ventilation. Presently, there is equipoise as to whether treating SDB prevents cardiovascular events.
View Article and Find Full Text PDFArticle Synopsis
- Paediatric hypertrophic cardiomyopathy (HCM) is linked to a higher risk of sudden cardiac death, leading to restrictions on physical activity; this inactivity, combined with rising youth obesity, may negatively impact cardiovascular health in these patients.* -
- The study involved 56 Canadian HCM patients aged 10-19 and evaluated their cardiovascular health using standardized questionnaires; results showed that many had poor health scores similar to those of the general Canadian youth population.* -
- Findings indicate a significant number of HCM patients have intermediate or poor cardiovascular health, underscoring the need for targeted interventions to encourage healthier lifestyles and improve overall cardiovascular wellbeing.*
Article Synopsis
- Ocean plastic pollution, particularly from nanoplastics, poses significant threats to marine life, especially fish, which are crucial for ecosystems and human consumption.
- The study focuses on how polystyrene nanoplastics transfer through the food chain using mahi-mahi larvae and rotifers, finding significant NP transfer influenced by exposure duration.
- While the larvae did not show major growth differences, histopathological analysis indicated intestinal damage, underscoring the need for further research into the ecological impacts of nanoplastics and food safety concerns.