Publications by authors named "T Purnak"
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and often debilitating condition requiring complex and individualized management. Over the past few decades, advancements in understanding IBD pathophysiology have led to a transformative shift in therapeutic approaches. This article provides a comprehensive overview of the evolution of IBD treatments, from early symptom-focused therapies to modern biologics, small molecule agents, and emerging treatment strategies.
View Article and Find Full Text PDFBackground And Aims: A limited number of drugs are used as standard or alternative therapies in autoimmune hepatitis (AIH). No specific recommendations are available for patients failing to respond to these therapies. We analyzed the efficacy and safety of infliximab in patients with AIH.
View Article and Find Full Text PDFPrevalence and significance of antimitochondrial antibodies in autoimmune hepatitis (AIH): Results from a large multicentre study of the International AIH Group.
Eur J Intern Med
October 2023
Article Synopsis
- * Among the 123 AMA-positive AIH patients studied, 5.1% had AMA, more commonly found in females; however, there were no significant differences in liver damage or treatment response compared to AMA-negative patients.
- * The presence of AMA is noteworthy mainly when linked to non-specific bile duct injury, as these patients have a higher risk of progressing to cirrhosis and developing further liver damage over time, emphasizing the need for thorough liver biopsy assessments.
Background And Aims: A few case reports of autoimmune hepatitis-like liver injury have been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We evaluated clinical features, treatment response and outcomes of liver injury following SARS-CoV-2 vaccination in a large case series.
Approach And Results: We collected data from cases in 18 countries.