The concentration of three anti-seizure medications in hair: the effects of hair color, controlling for dose and age.

Background: This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of dose, dose duration, and patient age for 140 clinical patients undergoing anti-seizure therapy. Three drugs are assessed: carbamazepine (40 patients), valproic acid (40 patients), and phenytoin (60 patients). The relationship between hair assay results, hair color, dose, dose duration, and age is modeled using an analysis of covariance.

Phenytoin concentration in head hair sections: a method to evaluate the history of drug use.

Phenytoin (PHT) levels were determined in sections of head hair taken from 60 patients (34 males and 26 females), aged 5 to 69 years, who were regularly receiving the drug. The hair sectional analysis included dissolution, liquid phase extraction procedures, and immunoassay (Abbott TDx) or high-pressure liquid chromatography (HPLC) analytical techniques. The values of PHT levels in the hair from the first section (close to the hair root) to the fifth section for female patients were 18.

Determination of phenytoin in sections of head hair: a preliminary study to evaluate the history of drug use.

Phenytoin (PH) levels were determined in the head hair of twenty five patients (fourteen males and eleven females, aged from five to seventy seven years old) who were receiving this drug chronically. The assay method involved sectional hair analysis by dissolution and liquid phase extraction procedures, using both high pressure liquid chromatography (HPLC) and immunoassay (Abbott TDx) techniques. Five sections were studied, the first being the one closet to the root.

Carbamazepine levels in head hair of patients under long-term treatment: a method to evaluate the history of drug use.

Carbamazepine (CBZ) concentrations were determined in the sections of head hair from 40 patients (22 males and 18 females), ages 5 to 81, who were receiving this drug systemically. Hair treatment included dissolution, liquid phase extraction procedures, and immunoassay (Abbott TDx) or high-pressure liquid chromatography (HPLC) analytical techniques. The mean values of CBZ levels in the hair from the 1st section (close to hair root) to the 5th section for female patients were 26.

Carbamazepine levels in the hair of patients under long-term treatment: a preliminary study.

Carbamazepine (CBZ) levels in the scalp hair of seventeen patients (ten male and seven female), aged from five to forty years old, receiving the drug systematically were determined after hair dissolution and solid-phase extraction procedures using both immunoassay (Abbott TDx) and gas chromatographic (GC) techniques. Carbamazepine levels in hair ranged from 13.9 to 66.