4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.

A wide variety of pathogens have acquired antimicrobial resistance as an inevitable evolutionary response to the extensive use of antibacterial agents. In particular, one of the most widely used antibiotic structural classes is the beta-lactams, in which the most common and the most efficient mechanism of bacterial resistance is the synthesis of beta-lactamases. Class C beta-lactamase enzymes are primarily cephalosporinases, mostly chromosomally encoded, and are inducible by exposure to some beta-lactam agents and resistant to inhibition by marketed beta-lactamase inhibitors.

EFNS guideline on mild traumatic brain injury: report of an EFNS task force.

In 1999, a Task Force on Mild Traumatic Brain Injury (MTBI) was set up under the auspices of the European Federation of Neurological Societies. Its aim was to propose an acceptable uniform nomenclature for MTBI and definition of MTBI, and to develop a set of rules to guide initial management with respect to ancillary investigations, hospital admission, observation and follow-up.

Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.

Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.

Can somatosensory system generate frequency following response?

The aim of this study was to establish whether functional characteristics of the somatosensory system structures in man comply with the frequency following response (FFR) generators. Somatosensory cerebral evoked potentials (SsCEP) were recorded by skin electrodes, and spinal somatosensory evoked potentials (SpEP) both by epidural and skin electrodes. In SpEP and SsCEP to trains of electrical or mechanical stimuli, a decrease of the amplitude to subsequent stimuli was found.

A noninvasive method of neurography in meralgia paraesthetica.

The lateral femoral cutaneous nerve (LFCN) becomes superficial 10 cm distal to the anterior superior iliac spine, where it can be located and stimulated by superficial electrodes. This is not the case in the inguinal region. In the present study the LFCN compound nerve action potential (NAP) was recorded with a pair of 8-cm-long strip electrodes placed on the anterolateral aspect of the thigh 25 cm distal to the stimulating electrodes.