Automated analysis of heart sound signals in screening for structural heart disease in children.

Unlabelled: Our aim was to investigate the ability of an artificial intelligence (AI)-based algorithm to differentiate innocent murmurs from pathologic ones. An AI-based algorithm was developed using heart sound recordings collected from 1413 patients at the five university hospitals in Finland. The corresponding heart condition was verified using echocardiography.

Heart rate in newborns is associated with age, sex and maternal levothyroxine therapy.

Aim: To evaluate the definition and causes of neonatal bradycardias.

Methods: This retrospective study included 135 term-born newborns referred for 24-hour Holter monitoring due to bradycardia. Bradycardia was defined as either a heart rate below 80 beats per minute (standard definition) or a heart rate below our recently published age-specific reference values for neonatal heart rate.

Recessive TMOD1 mutation causes childhood cardiomyopathy.

Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic mutations. Through exome sequencing, we report a homozygous variant in tropomodulin 1 (TMOD1; c.565C>T, p.

Major congenital heart defects are rarely diagnosed after newborns' hospital discharge with modern screening.

Aim: Our aim was to assess undiagnosed congenital heart defects (CHD) after newborns' hospital discharge in patients with a murmur or CHD suspicion, to find out the signs that predict CHDs and to estimate the costs of the examinations.

Methods: We reviewed retrospective medical records of patients (n = 490) referred for the evaluation of CHD suspicion during 2017-2018.

Results: The median age of the patients was 2.

Younger postnatal age is associated with a lower heart rate on Holter monitoring during the first week of life.

Unlabelled: To evaluate heart rate (HR), the presence of extrasystoles and other Holter findings among healthy newborns, and to collect data for new normal limits for Holter parameters in newborns. For this cross-sectional study, 70 healthy term newborns were recruited to undergo 24-h Holter monitoring. Linear regression analysis was used in HR analyses.