Publications by authors named "T Pooja"
Background: Acne scarring commonly seen in young adults causes marked psychological distress. Commonly used procedural treatments for post-acne scarring have limited efficacy. This prospective, randomized study was undertaken to evaluate the efficacy and adverse effects offractional CO2 laser, microneedling, and platelet-rich plasma (PRP) in post-acne scarring.
View Article and Find Full Text PDFEmodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620.
Eur J Pharmacol
November 2014
Wnt signaling is involved in the regulation of cell proliferation, differentiation and apoptosis. Its aberrant activation is a key event in the pathogenesis and progression of human colorectal cancers. Dietary phytochemicals are gaining importance as chemotherapeutic agents owing to their potential to prevent, delay or reverse oncogenesis.
View Article and Find Full Text PDFCNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.
Diabetol Metab Syndr
August 2014
Article Synopsis
- Retinoid X Receptors (RXR) play important roles in regulating metabolism, and rexinoids that activate RXR are being explored as treatments for metabolic syndrome; however, some past rexinoids caused adverse effects like increased triglycerides and liver issues.
- This study focuses on evaluating a new rexinoid, CNX-013-B2, for treating metabolic syndrome by selectively activating specific RXR partner pathways to improve insulin resistance.
- Results showed that CNX-013-B2 led to significant reductions in glucose and cholesterol levels in both ob/ob and high-fat diet mice, suggesting its potential benefits for managing metabolic risk factors.